Multiomics spatial biology imaging
Drive research innovation.
Find actionable information.
Multiomics Molecular Insight
A single MALDI Imaging measurement produces up to several thousands of distribution maps, or ion images, to reveal greater insight and understanding of molecular makeup and regional heterogeneity.
With this multiomics solution, go beyond RNA and protein expression, to spatially co-localize selected proteins with metabolites, lipids, and N-glycans, within the tissue microarchitecture.
Integrate multiple data layers with microscopy or histology data for versatile analysis.
Molecular Imaging Defined
Whether your research is focused on plant metabolomics, biochemistry of cellular processes, biomarkers of disease development or treatment, or microbial interactions, molecular imaging can deliver new insight to your work. Key to this is the ability to integrate MALDI Imaging with other imaging modalities you may already be using, such as fluorescence microscopy or histology.
Drive innovation in your disease-based research with spatial contextualization a variety of molecular classes inaccessible by other molecular imaging technologies.
Revolutionize pre-clinical drug discovery pipelines by providing direct distribution monitoring of therapeutic compounds and their metabolites.
MALDI Imaging Technologies
Using MALDI to spatially measure molecular signatures
Images are generated by collecting MALDI data in a grid pattern on the sample surface. The user-defined size of the virtual grid establishes image resolution.
Using the scanning smartbeam 3D laser, true square pixels ensure no oversampling and complete tissue coverage. Each resulting mass spectrum is a molecular signature of that sampled area. The distribution of each detected ion in the sampled area can be visualized.
Ease of preparation and analysis
Fresh frozen or FFPE tissue are sectioned and mounted on IntelliSlides®, then spray coated with matrix. Data acquisition with the automated SCiLS™ autopilot workflow gives a simple and reproducible setup of MALDI Imaging measurements.
The automated workflow is avilable for the timsTOF series, rapifleX®, and neoflex™.
Platforms built with inspired innovation
From biomarker discovery science to translational studies, Bruker's 30 years of MALDI expertise leads the field. The fleX series, rapifleX, and neofleX include smartbeam 3D laser technology for highest throughput. Long life detectors ensure maximum utility. Bruker systems are the most widely used imaging systems found in the scientific literature.
Direct results for efficient research
Workflow flexibility with smartbeam-II laser traditional axial-TOF applications. A wide range of utility including intact protein analysis, glycoproteomics, biologics or oligo QC, polymer analysis, and imaging.
Highest Molecular Specificity
Untargeted and targeted studies of smaller molecules demand high analytical performance for separating isobars and/or near-isobars. Bruker’s MRMS and timsTOF fleX systems meet the challenge by offering the highest molecular specificity available.
For targeted and untargeted imaging studies, Bruker’s solariX and scimaX® Magnetic Resonance Mass Spectrometers (MRMS) offer eXtreme mass resolution. At imaging speeds, achieve > 290,000 mass resolution at m/z 400 capable of differentiating and mapping compounds that differ by only a few mDa.
Customized MRMS – world’s most advanced mass spectrometers.
Differentiate yourself with customized advanced mass spectrometry: Bruker matches world class technologies in flexible customized instrumentation for your ultimate scientific and research needs.
SCiLS™ Software Solution: Turn data into knowledge
Use our industry-leading software for analysis and visualization of MALDI Imaging data.
Advanced data processing and analysis includes machine learning algorithms, unsupervised spatial segmentation, classification models, and additional statistical analyses.
An easy-to-use platform for sharing and viewing targeted mass lists is possible with SCiLS™ Scope. Easy image review that is ideal for sharing images across collaborators or users.
For Research Use Only. Not for use in clinical diagnostic procedures.